The Global Ocean Ship-based Hydrographic Investigations Program (GO-SHIP) brings together scientists with interests in physical oceanography, the carbon cycle, marine biogeochemistry and ecosystems, and other users and collectors of ocean interior data, and coordinates a network of globally sustained hydrographic sections as part of the global ocean/climate observing system including physical oceanography, the carbon cycle, marine biogeochemistry and ecosystems. GO-SHIP provides approximately decadal resolution of the changes in inventories of heat, freshwater, carbon, oxygen, nutrients and transient tracers, covering the ocean basins from coast to coast and full depth (top to bottom), with global measurements of the highest required accuracy to detect these changes. The GO-SHIP principal scientific objectives are: (1) understanding and documenting the large-scale ocean water property distributions, their changes, and drivers of those changes, and (2) addressing questions of how a future ocean will increase in dissolved inorganic carbon, become more acidified and more stratified, and experience changes in circulation and ventilation processes due to global warming and altered water cycle.