In integrated multi-trophic aquaculture (IMTA), multiple aquatic species from different trophic levels are farmed together. Thus, waste from one species can be used as input (fertiliser and food) for another species. The EU-funded ASTRAL project will develop IMTA production chains for the Atlantic markets. Focusing on a regional challenge-based perspective, it will bring together labs in Ireland and Scotland (open offshore labs), South Africa (flow-through inshore) and Brazil (recirculation inshore) as well as Argentina (prospective IMTA lab). The aim is to increase circularity by as much as 60 % compared to monoculture baseline aquaculture and to boost revenue diversification for aquaculture producers. ASTRAL will share, integrate, and co-generate knowledge, technology and best practices, fostering a collaborative ecosystem along the Atlantic.